DYNC2I2

Across TCGA cell cohorts, DYNC2I2 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DYNC2I2-associated genes across cancer lineages are USP17L17, HK3, and ETV3L. Each is linked with DYNC2I2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DYNC2I2-to-partner and partner-to-DYNC2I2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP17L17 grouped by DYNC2I2-low versus DYNC2I2-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYNC2I2→partner) and Y-score (partner→DYNC2I2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	USP17L17 →	+0.013	+5.285	<.001	.003	3	1
LARGE_INTESTINE	HK3 →	+0.217	+3.648	.002	.002	3	1
LARGE_INTESTINE	ETV3L →	+0.006	+2.882	.002	.005	3	1
LARGE_INTESTINE	TIFAB →	+0.003	+3.240	<.001	.004	3	1
OVARY	XAGE5 →	+0.255	+5.196	<.001	.005	3	1
LARGE_INTESTINE	ACTL7B →	+0.063	+3.029	.002	.003	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

USP17L17 by DYNC2I2 expression — STOMACH

Explore this box plot interactively →