DYNC2I1

Across TCGA pan-cancer cohorts, DYNC2I1 mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of DYNC2I1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where DYNC2I1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types DYNC2I1 is over-expressed in tumor, although a few such as LUAD and LSCC show the opposite, repressed pattern.

LUAD and LSCC are the cancer types where DYNC2I1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DYNC2I1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	All	−0.204	.002	4	view →
LSCC	All	All	−0.199	.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

DYNC2I1–LUAD

Open the LUAD breakdown →