DYNC2I1

Across TCGA patient cohorts, DYNC2I1 protein abundance is significantly associated with the RNA expression of many other genes, with 9,727 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible DYNC2I1-associated genes across cancer lineages are TSNAXIP1, DNAH7, and DNAI4. Each is linked with DYNC2I1 in more than 5 cancer types. Because this analysis shows association rather than direction, both DYNC2I1-to-partner and partner-to-DYNC2I1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DYNC2I1 versus TSNAXIP1 in UCEC, with a Pearson correlation of 0.59.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYNC2I1→partner) and Y-score (partner→DYNC2I1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TSNAXIP1 →	+0.834	+0.442	<.001	<.001	3	6
UCEC	DNAH7 →	+1.043	+0.537	<.001	<.001	3	6
UCEC	DNAI4 →	+1.080	+0.540	<.001	<.001	3	6
UCEC	CFAP43 →	+1.856	+0.580	<.001	<.001	3	6
BRCA	SPEF1 →	+1.296	+0.588	<.001	<.001	3	5
UCEC	TTLL9 →	+1.281	+0.567	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,727 associations by consensus.

DYNC2I1 vs TSNAXIP1 — UCEC

Explore this scatter interactively →