DYNC2I1

Across TCGA patient cohorts, DYNC2I1 mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DYNC2I1-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and A-Raf_pS299. Each is linked with DYNC2I1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DYNC2I1-to-partner and partner-to-DYNC2I1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by DYNC2I1-low versus DYNC2I1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYNC2I1→partner) and Y-score (partner→DYNC2I1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.198	-1.321	.004	.005	3	2
UCEC	eIF4E →	+0.168	+2.261	.004	<.001	3	2
UCEC	A-Raf_pS299 →	-0.081	-1.321	.014	.027	3	2
COAD	GAPDH →	+1.027	+3.008	<.001	.019	3	2
UCEC	INPP4B →	-0.270	-2.137	.002	<.001	3	2
UCEC	MEK1 →	+0.400	+2.584	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

EGFR_pY1068 by DYNC2I1 expression — UCEC

Explore this box plot interactively →