DYNC2I1

Across TCGA cell cohorts, DYNC2I1 mutation is significantly associated with the RNA expression of many other genes, with 797 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DYNC2I1-associated genes across cancer lineages are FSHR, KLHL2, and ZNF391. Each is linked with DYNC2I1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DYNC2I1-to-partner and partner-to-DYNC2I1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FSHR grouped by DYNC2I1-low versus DYNC2I1-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYNC2I1→partner) and Y-score (partner→DYNC2I1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	FSHR →	+0.013	+4.906	<.001	.006	3	2
LARGE_INTESTINE	KLHL2 →	+0.716	+3.628	<.001	<.001	3	2
LARGE_INTESTINE	ZNF391 →	+1.009	+3.321	<.001	.002	3	2
LARGE_INTESTINE	PEX1 →	+0.502	+3.628	.001	<.001	3	2
LARGE_INTESTINE	LRRC41 →	+0.686	+3.628	<.001	<.001	3	2
LARGE_INTESTINE	CNNM2 →	+0.624	+3.628	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 797 associations by consensus.

FSHR by DYNC2I1 expression — OESOPHAGUS

Explore this box plot interactively →