Across TCGA pan-cancer cohorts, DYNC2H1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated DYNC2H1 data layer compared with 25 for mass-spec protein and 13 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher DYNC2H1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated DYNC2H1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

CCRCC, PDAC, and LSCC are the cancer types where DYNC2H1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	1.000	0.626	.001	26	view →
PDAC	OS	Median	All	0.371	0.560	.019	8	view →
LSCC	DFS	Median	All	0.515	0.936	.013	7	view →
LUAD	DFS	Median	III,IV	0.663	0.828	.032	5	view →
GBM	OS	Median	All	0.606	0.462	.049	1	view →
HNSC	DFS	Quartile	All	0.902	0.757	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

Exploration

Same gene, other analysis: DYNC2H1 tumor-vs-normal RNA expression · all DYNC2H1 data types