Across TCGA cell cohorts, DYNC2H1 mutation is significantly associated with the RNA expression of many other genes, with 836 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DYNC2H1-associated genes across cancer lineages are SUCLG1, RPL4, and DNAJA2. Each is linked with DYNC2H1 in more than 2 cancer types. Because this analysis shows association rather than direction, both DYNC2H1-to-partner and partner-to-DYNC2H1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYNC2H1→partner) and Y-score (partner→DYNC2H1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SUCLG1 →	+0.389	+3.169	.005	.006	3	3
LARGE_INTESTINE	RPL4 →	+0.340	+2.115	.006	.004	3	3
LARGE_INTESTINE	DNAJA2 →	+0.332	+1.652	.006	.002	3	3
URINARY_TRACT	TGM6 →	+0.048	+4.050	<.001	.002	3	2
PANCREAS	EFCAB3 →	+0.022	+4.029	<.001	.007	3	2
OESOPHAGUS	OR56A5 →	+0.139	+3.115	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 836 associations by consensus.

Exploration

DYNC2H1 survival (RNA) · tumor vs normal (RNA) · all DYNC2H1 data types