DYNC1LI2

Across TCGA patient cohorts, DYNC1LI2 mutation is significantly associated with the RNA expression of many other genes, with 1,622 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DYNC1LI2-associated genes across cancer lineages are SEPTIN7P4, SNORD116-26, and DDAH1. Each is linked with DYNC1LI2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DYNC1LI2-to-partner and partner-to-DYNC1LI2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEPTIN7P4 grouped by DYNC1LI2-low versus DYNC1LI2-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYNC1LI2→partner) and Y-score (partner→DYNC1LI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	SEPTIN7P4 →	+0.096	+6.040	<.001	.001	3	2
BLCA	SNORD116-26 →	+0.658	+4.568	<.001	.004	3	2
UCEC	DDAH1 →	+0.648	+2.606	<.001	<.001	3	2
UCEC	PYHIN1 →	+0.398	+1.595	.001	.003	3	2
UCEC	ADAL →	+0.341	+2.255	.009	.001	3	2
SKCM	RNU6-645P →	+0.185	+3.242	.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,622 associations by consensus.

SEPTIN7P4 by DYNC1LI2 expression — BLCA

Explore this box plot interactively →