DYNC1LI2

Across TCGA patient cohorts, DYNC1LI2 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DYNC1LI2-associated genes across cancer lineages are Fibronectin, 14-3-3_beta, and EGFR_pY1068. Each is linked with DYNC1LI2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DYNC1LI2-to-partner and partner-to-DYNC1LI2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fibronectin grouped by DYNC1LI2-low versus DYNC1LI2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYNC1LI2→partner) and Y-score (partner→DYNC1LI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Fibronectin →	-0.304	-1.896	.006	.015	3	2
UCEC	14-3-3_beta →	-0.099	-2.195	.003	.009	3	1
UCEC	EGFR_pY1068 →	-0.190	-1.514	.026	.015	3	1
UCEC	eIF4E →	+0.210	+2.137	.003	.001	3	1
UCEC	ERK2 →	+0.164	+2.321	.012	.005	3	1
UCEC	GATA6 →	-0.116	-1.859	.033	.048	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Fibronectin by DYNC1LI2 expression — UCEC

Explore this box plot interactively →