DYNC1LI1

Across TCGA pan-cancer cohorts, DYNC1LI1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DYNC1LI1 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher DYNC1LI1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DYNC1LI1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

LSCC, CCRCC, and LUAD are the cancer types where DYNC1LI1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	1.000	0.314	.006	11	view →
CCRCC	DFS	Tertile	II,III,IV	0.830	0.418	.012	8	view →
LUAD	OS	Median	III,IV	0.311	0.754	.008	8	view →
GBM	OS	Quartile	All	0.178	0.570	.016	6	view →
HNSC	DFS	Quartile	III,IV	0.901	0.609	.014	5	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DYNC1LI1–LSCC (DFS)

Open the LSCC breakdown →