DYNC1LI1

Across TCGA cell cohorts, DYNC1LI1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,142 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DYNC1LI1-associated GO terms across cancer lineages are Positive regulation of spindle checkpoint, Positive regulation of mitotic cell cycle spindle assembly checkpoint, and Regulation of chromosome separation. Each is linked with DYNC1LI1 in more than 17 cancer types. Because this analysis shows association rather than direction, both DYNC1LI1-to-partner and partner-to-DYNC1LI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of spindle checkpoint grouped by DYNC1LI1-low versus DYNC1LI1-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DYNC1LI1→partner) and Y-score (partner→DYNC1LI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Positive regulation of spindle checkpoint →	+0.160	+1.113	<.001	<.001	3	18
KIDNEY	Positive regulation of mitotic cell cycle spindle assembly checkpoint →	+0.160	+1.113	<.001	<.001	3	18
KIDNEY	Regulation of chromosome separation →	+0.174	+1.122	<.001	<.001	3	18
URINARY_TRACT	Regulation of spindle checkpoint →	+0.134	+0.857	.003	.004	3	17
URINARY_TRACT	Regulation of mitotic cell cycle spindle assembly checkpoint →	+0.133	+0.857	.003	.004	2	18
KIDNEY	Regulation of mitotic sister chromatid separation →	+0.165	+1.084	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,142 associations by consensus.

Positive regulation of spindle checkpoint by DYNC1LI1 expression — KIDNEY

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