DYNC1I2

Across TCGA pan-cancer cohorts, DYNC1I2 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of DYNC1I2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where DYNC1I2 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types DYNC1I2 is over-expressed in tumor, although a few such as COAD and LSCC show the opposite, repressed pattern.

COAD, LSCC, and HNSC are the cancer types where DYNC1I2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DYNC1I2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	−0.254	<.001	11	view →
LSCC	Female	All	−0.303	<.001	9	view →
HNSC	Male	All	−0.224	<.001	8	view →
LUAD	Male	All	−0.127	<.001	8	view →
CCRCC	Male	III,IV	−0.117	<.001	8	view →
PDAC	Female	All	−0.183	.005	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

DYNC1I2–COAD

Open the COAD breakdown →