DYNC1I2

Across TCGA patient cohorts, DYNC1I2 protein abundance is significantly associated with the RNA expression of many other genes, with 8,701 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DYNC1I2-associated genes across cancer lineages are CINP, ACTR10, and KLHDC2. Each is linked with DYNC1I2 in more than 5 cancer types. Because this analysis shows association rather than direction, both DYNC1I2-to-partner and partner-to-DYNC1I2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DYNC1I2 versus CINP in LSCC, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYNC1I2→partner) and Y-score (partner→DYNC1I2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CINP →	+0.389	+0.178	.001	<.001	3	6
COAD	ACTR10 →	+0.448	+0.119	<.001	<.001	3	5
COAD	KLHDC2 →	+0.433	+0.147	<.001	<.001	3	5
PDAC	COA8 →	+0.369	+0.286	<.001	<.001	3	5
GBM	EXOC5 →	+0.576	+0.243	<.001	<.001	3	5
HNSC	BCL2A1 →	-1.452	-0.260	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,701 associations by consensus.

DYNC1I2 vs CINP — LSCC

Explore this scatter interactively →