DYNC1I2

Across TCGA patient cohorts, DYNC1I2 mutation is significantly associated with the RNA expression of many other genes, with 1,388 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DYNC1I2-associated genes across cancer lineages are MTCO1P35, VPS33B, and C22orf46. Each is linked with DYNC1I2 in more than 2 cancer types. Because this analysis shows association rather than direction, both DYNC1I2-to-partner and partner-to-DYNC1I2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTCO1P35 grouped by DYNC1I2-low versus DYNC1I2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYNC1I2→partner) and Y-score (partner→DYNC1I2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MTCO1P35 →	+0.335	+2.621	<.001	.001	3	3
UCEC	VPS33B →	+0.297	+2.413	.002	<.001	3	2
UCEC	C22orf46 →	+0.356	+2.606	.004	.005	3	2
UCEC	NPIPB9 →	+0.083	+3.005	.003	<.001	3	2
UCEC	RNA5SP420 →	+0.590	+1.879	<.001	.003	3	2
UCEC	RNA5SP423 →	+0.554	+1.887	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,388 associations by consensus.

MTCO1P35 by DYNC1I2 expression — UCEC

Explore this box plot interactively →