DYNC1I2

Across TCGA patient cohorts, DYNC1I2 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DYNC1I2-associated genes across cancer lineages are 14-3-3_beta, A-Raf_pS299, and ERK2. Each is linked with DYNC1I2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DYNC1I2-to-partner and partner-to-DYNC1I2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by DYNC1I2-low versus DYNC1I2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYNC1I2→partner) and Y-score (partner→DYNC1I2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.131	-3.432	.001	.005	3	1
UCEC	A-Raf_pS299 →	-0.197	-2.584	<.001	.010	3	1
UCEC	ERK2 →	+0.189	+2.321	.017	.034	3	1
UCEC	ACC1 →	+0.377	+3.183	.012	.009	3	1
UCEC	Heregulin →	-0.132	-2.308	.009	.033	3	1
UCEC	JNK_pT183_Y185 →	-0.227	-3.321	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

14-3-3_beta by DYNC1I2 expression — UCEC

Explore this box plot interactively →