DYNC1I2

Across TCGA cell cohorts, DYNC1I2 mutation is significantly associated with the RNA expression of many other genes, with 349 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DYNC1I2-associated genes across cancer lineages are PPP2R5D, ATP5PB, and GLIPR2. Each is linked with DYNC1I2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DYNC1I2-to-partner and partner-to-DYNC1I2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP2R5D grouped by DYNC1I2-low versus DYNC1I2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYNC1I2→partner) and Y-score (partner→DYNC1I2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PPP2R5D →	+0.675	+3.212	.002	.006	3	1
LARGE_INTESTINE	ATP5PB →	+0.480	+3.212	.004	.006	3	1
LARGE_INTESTINE	GLIPR2 →	+1.140	+3.212	.002	.006	3	1
LARGE_INTESTINE	ALKBH7 →	+0.463	+3.212	.005	.006	3	1
LARGE_INTESTINE	TNFSF9 →	+1.669	+3.212	<.001	.006	3	1
LARGE_INTESTINE	SMPDL3B →	+1.183	+3.212	.009	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 349 associations by consensus.

PPP2R5D by DYNC1I2 expression — LARGE_INTESTINE

Explore this box plot interactively →