DYNC1I1

Across TCGA pan-cancer cohorts, DYNC1I1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DYNC1I1 data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher DYNC1I1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DYNC1I1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, CCRCC, and LUAD are the cancer types where DYNC1I1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.511	0.296	.008	21	view →
CCRCC	OS	Median	IV	1.000	0.202	.034	6	view →
LUAD	DFS	Tertile	III,IV	0.318	0.659	.032	4	view →
HNSC	OS	Median	II,III,IV	1.000	0.950	.023	4	view →
GBM	OS	Tertile	All	0.297	0.639	.028	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DYNC1I1–PDAC (DFS)

Open the PDAC breakdown →