DYNC1I1

Across TCGA patient cohorts, DYNC1I1 protein abundance is significantly associated with the protein abundance of many other proteins, with 23,894 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DYNC1I1-associated proteins across cancer lineages are CRTAC1, PRPF8, and TBC1D22B_S141. Each is linked with DYNC1I1 in more than 5 cancer types. Because this analysis shows association rather than direction, both DYNC1I1-to-partner and partner-to-DYNC1I1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DYNC1I1 versus CRTAC1 in GBM, with a Pearson correlation of 0.60.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DYNC1I1→partner) and Y-score (partner→DYNC1I1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CRTAC1 →	+0.679	+0.601	<.001	<.001	3	5
GBM	PRPF8 →	-0.268	-0.486	<.001	<.001	3	5
BRCA	TBC1D22B_S141 →	-1.057	-0.478	.002	<.001	3	5
GBM	TMOD2 →	+0.630	+0.696	<.001	<.001	3	5
GBM	DYNC1I1_S179 →	+1.177	+0.765	<.001	<.001	3	5
GBM	MTURN →	+0.945	+0.741	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 23,894 associations by consensus.

DYNC1I1 vs CRTAC1 — GBM

Explore this scatter interactively →