DYNC1I1

Across TCGA patient cohorts, DYNC1I1 mutation is significantly associated with the RNA expression of many other genes, with 3,911 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DYNC1I1-associated genes across cancer lineages are HADHB, REEP5, and SAT2. Each is linked with DYNC1I1 in more than 2 cancer types. Because this analysis shows association rather than direction, both DYNC1I1-to-partner and partner-to-DYNC1I1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HADHB grouped by DYNC1I1-low versus DYNC1I1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYNC1I1→partner) and Y-score (partner→DYNC1I1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	HADHB →	+0.322	+3.214	.003	.009	3	3
UCEC	REEP5 →	+0.259	+2.280	.001	<.001	3	3
UCEC	SAT2 →	+0.457	+1.906	<.001	.001	3	3
UCEC	PSMB6 →	+0.362	+1.409	<.001	.002	3	3
UCEC	OXA1L →	+0.268	+2.179	<.001	<.001	3	3
UCEC	CTLA4 →	+0.657	+1.441	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,911 associations by consensus.

HADHB by DYNC1I1 expression — LUAD

Explore this box plot interactively →