DYNC1I1

Across TCGA patient cohorts, DYNC1I1 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DYNC1I1-associated genes across cancer lineages are MSH2, PDCD4, and ASNS. Each is linked with DYNC1I1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DYNC1I1-to-partner and partner-to-DYNC1I1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by DYNC1I1-low versus DYNC1I1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYNC1I1→partner) and Y-score (partner→DYNC1I1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.178	-1.558	.015	.032	3	2
UCEC	PDCD4 →	-0.467	-2.405	.001	.003	3	2
UCEC	ASNS →	+0.310	+1.502	.007	.027	3	2
UCEC	Caspase-7-cleavedD198 →	+0.519	+1.584	.006	.032	3	2
UCEC	CDK1_pY15 →	+0.146	+1.722	.033	.025	3	2
UCEC	Cyclin-B1 →	+0.419	+1.700	.019	.040	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

MSH2 by DYNC1I1 expression — UCEC

Explore this box plot interactively →