DYNC1I1

Across TCGA cell cohorts, DYNC1I1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,726 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible DYNC1I1-associated GO terms across cancer lineages are Negative regulation of syncytium formation by plasma membrane fusion, Purine nucleoside triphosphate metabolic process, and ATP metabolic process. Each is linked with DYNC1I1 in more than 12 cancer types. Because this analysis shows association rather than direction, both DYNC1I1-to-partner and partner-to-DYNC1I1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of syncytium formation by plasma membrane fusion grouped by DYNC1I1-low versus DYNC1I1-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DYNC1I1→partner) and Y-score (partner→DYNC1I1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Negative regulation of syncytium formation by plasma membrane fusion →	+0.064	+0.917	<.001	.002	3	13
UPPER_AERODIGESTIVE_TRACT	Purine nucleoside triphosphate metabolic process →	+0.083	+1.352	<.001	.002	3	12
UPPER_AERODIGESTIVE_TRACT	ATP metabolic process →	+0.091	+1.171	<.001	.006	3	12
UPPER_AERODIGESTIVE_TRACT	Nucleoside triphosphate metabolic process →	+0.084	+1.270	<.001	.004	3	12
UPPER_AERODIGESTIVE_TRACT	Ribonucleoside triphosphate biosynthetic process →	+0.090	+1.216	.001	.007	3	12
BLOOD_Leukemia	Negative regulation of myoblast fusion →	+0.063	+0.918	<.001	.002	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,726 associations by consensus.

Negative regulation of syncytium formation by plasma membrane fusion by DYNC1I1 expression — BLOOD_Leukemia

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