DYNC1I1

Across TCGA cell cohorts, DYNC1I1 mutation is significantly associated with the RNA expression of many other genes, with 376 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DYNC1I1-associated genes across cancer lineages are OR56A5, TRIM49B, and ARGFX. Each is linked with DYNC1I1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DYNC1I1-to-partner and partner-to-DYNC1I1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR56A5 grouped by DYNC1I1-low versus DYNC1I1-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYNC1I1→partner) and Y-score (partner→DYNC1I1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	OR56A5 →	+0.045	+4.736	<.001	.009	3	2
BLOOD_Leukemia	TRIM49B →	+0.111	+3.874	<.001	.005	3	2
BLOOD_Lymphoma	ARGFX →	+0.020	+3.169	.001	.008	3	2
LARGE_INTESTINE	WNT3A →	+0.238	+2.169	<.001	.007	3	2
BLOOD_Myeloma	OR2A14 →	+0.033	+4.807	<.001	.006	3	1
URINARY_TRACT	ACCSL →	+0.013	+5.087	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 376 associations by consensus.

OR56A5 by DYNC1I1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →