Across TCGA pan-cancer cohorts, DYNC1H1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DYNC1H1 data layer compared with 25 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DYNC1H1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DYNC1H1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

HNSC, LUAD, and GBM are the cancer types where DYNC1H1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.913	0.651	.002	60	view →
LUAD	DFS	Median	II,III,IV	0.321	0.658	.003	45	view →
GBM	OS	Quartile	All	0.150	0.602	.004	11	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	9	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: DYNC1H1 tumor-vs-normal RNA expression · all DYNC1H1 data types