Across TCGA patient cohorts, DYNC1H1 mutation is significantly associated with the total protein of many other genes, with 89 significant associations in total. COAD shows the largest number of these associations.

The most reproducible DYNC1H1-associated genes across cancer lineages are Cyclin-B1, Caspase-7-cleavedD198, and 4E-BP1. Each is linked with DYNC1H1 in more than 7 cancer types. Because this analysis shows association rather than direction, both DYNC1H1-to-partner and partner-to-DYNC1H1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYNC1H1→partner) and Y-score (partner→DYNC1H1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Cyclin-B1 →	+0.375	+2.459	.029	.018	3	8
COAD	Caspase-7-cleavedD198 →	+1.185	+2.409	<.001	<.001	3	6
UCEC	4E-BP1 →	+0.217	+1.893	<.001	<.001	3	6
UCEC	PDCD4 →	-0.349	-1.192	<.001	.004	3	5
COAD	Cyclin-E2 →	+0.195	+2.415	.003	.002	3	4
BLCA	FoxM1 →	+0.156	+2.356	.046	.017	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 89 associations by consensus.

Exploration

DYNC1H1 survival (RNA) · tumor vs normal (RNA) · all DYNC1H1 data types