Across TCGA cell cohorts, DYNC1H1 mutation is significantly associated with the RNA expression of many other genes, with 2,590 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DYNC1H1-associated genes across cancer lineages are SLC12A1, KCTD1, and MSH4. Each is linked with DYNC1H1 in more than 2 cancer types. Because this analysis shows association rather than direction, both DYNC1H1-to-partner and partner-to-DYNC1H1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYNC1H1→partner) and Y-score (partner→DYNC1H1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	SLC12A1 →	+0.009	+2.787	<.001	.002	3	3
BLOOD_Leukemia	KCTD1 →	+1.311	+2.700	<.001	.002	3	3
LARGE_INTESTINE	MSH4 →	+0.307	+2.242	<.001	<.001	3	3
LARGE_INTESTINE	MINDY4 →	+0.478	+1.628	.005	.002	3	3
LARGE_INTESTINE	CCNC →	+0.609	+1.969	<.001	<.001	3	3
LARGE_INTESTINE	CTH →	+1.051	+2.459	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,590 associations by consensus.

Exploration

DYNC1H1 survival (RNA) · tumor vs normal (RNA) · all DYNC1H1 data types