DYNAP

Across TCGA patient cohorts, DYNAP mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible DYNAP-associated genes across cancer lineages are ACC_pS79, Heregulin, and AMPK_alpha. Each is linked with DYNAP in more than 1 cancer types. Because this analysis shows association rather than direction, both DYNAP-to-partner and partner-to-DYNAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC_pS79 grouped by DYNAP-low versus DYNAP-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYNAP→partner) and Y-score (partner→DYNAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ACC_pS79 →	+0.241	+1.700	.033	.040	3	1
SKCM	Heregulin →	+0.145	+1.749	.030	.049	3	1
SKCM	AMPK_alpha →	+0.118	+2.115	.030	.017	3	1
SKCM	STAT3_pY705 →	-0.266	-1.584	.012	.035	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

ACC_pS79 by DYNAP expression — SKCM

Explore this box plot interactively →