DYM

Across TCGA pan-cancer cohorts, DYM mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DYM data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher DYM mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DYM expression acts as an unfavorable survival marker, although some lineages such as UCEC and PDAC show a favorable association.

UCEC, LSCC, and HNSC are the cancer types where DYM mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.953	0.848	.015	10	view →
LSCC	DFS	Quartile	All	0.892	1.000	.003	10	view →
HNSC	DFS	Quartile	IV	0.581	0.915	.006	10	view →
PDAC	DFS	Median	II,III,IV	0.349	0.195	.012	8	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

DYM–UCEC (DFS)

Open the UCEC breakdown →