DYM

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, DYM protein abundance is significantly associated with the RNA expression of many other genes, with 5,166 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible DYM-associated genes across cancer lineages are FN1, LRRC4C, and ADRA2A. Each is linked with DYM in more than 2 cancer types. Because this analysis shows association rather than direction, both DYM-to-partner and partner-to-DYM results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DYM versus FN1 in OV, with a Pearson correlation of 0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYM→partner) and Y-score (partner→DYM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVFN1 →+1.883+0.340<.001.00133
CCRCCLRRC4C →+0.605+0.151.002<.00133
UCECADRA2A →+1.268+0.235<.001.00133
UCECLPAR1 →+0.750+0.268.002<.00133
OVCHCHD10 →-1.045-0.398<.001<.00133
UCECATP2B2 →-1.024-0.244.003.00133
Each partner links to its Q-omics profile. Showing the 6 strongest of 5,166 associations by consensus.

DYM vs FN1 — OV

Per-sample scatter of DYM vs FN1 in OV (Pearson r = 0.33).

Explore this scatter interactively →

Exploration