DYM

Across TCGA patient cohorts, DYM mutation is significantly associated with the RNA expression of many other genes, with 4,487 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DYM-associated genes across cancer lineages are OR4K2, FAM71B, and KRTAP8-1. Each is linked with DYM in more than 1 cancer types. Because this analysis shows association rather than direction, both DYM-to-partner and partner-to-DYM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4K2 grouped by DYM-low versus DYM-high in SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYM→partner) and Y-score (partner→DYM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	OR4K2 →	+0.152	+5.624	<.001	.003	3	2
SCLC	FAM71B →	+0.079	+4.847	<.001	.009	3	2
SCLC	KRTAP8-1 →	+0.232	+5.624	<.001	.003	3	2
LIHC	RNU6-933P →	+0.379	+5.268	<.001	.006	3	2
LIHC	ATP13A5-AS1 →	+0.244	+6.008	<.001	.002	3	2
LUAD	MIR629 →	+0.405	+4.684	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,487 associations by consensus.

OR4K2 by DYM expression — SCLC

Explore this box plot interactively →