DYM

Across TCGA patient cohorts, DYM mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DYM-associated genes across cancer lineages are FoxM1, p38-MAPK_pT180_Y182, and ASNS. Each is linked with DYM in more than 1 cancer types. Because this analysis shows association rather than direction, both DYM-to-partner and partner-to-DYM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by DYM-low versus DYM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYM→partner) and Y-score (partner→DYM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.232	+2.263	.006	<.001	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.384	-1.638	.009	.006	3	2
UCEC	ASNS →	+0.297	+1.678	.012	.021	3	2
UCEC	Caspase-7-cleavedD198 →	+0.553	+1.938	.004	.001	3	2
UCEC	Cyclin-E2 →	+0.136	+1.652	.014	.006	3	2
UCEC	EGFR_pY1068 →	-0.234	-2.000	.004	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

FoxM1 by DYM expression — UCEC

Explore this box plot interactively →