DYM

Across TCGA cell cohorts, DYM mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DYM-associated genes across cancer lineages are KRTAP19-4, SCYGR8, and MRAP. Each is linked with DYM in more than 1 cancer types. Because this analysis shows association rather than direction, both DYM-to-partner and partner-to-DYM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP19-4 grouped by DYM-low versus DYM-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYM→partner) and Y-score (partner→DYM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	KRTAP19-4 →	+0.169	+4.681	<.001	.003	3	1
LUNG_NSCLC_LUAD	SCYGR8 →	+0.013	+4.078	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	MRAP →	+0.028	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	TSPY3 →	+0.626	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	C1orf232 →	+0.084	+4.736	<.001	.009	3	1
LARGE_INTESTINE	ACADL →	+0.402	+3.748	.006	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

KRTAP19-4 by DYM expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →