DYDC2

Across TCGA patient cohorts, DYDC2 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DYDC2-associated genes across cancer lineages are Notch1, C-Raf, and JNK_pT183_Y185. Each is linked with DYDC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DYDC2-to-partner and partner-to-DYDC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by DYDC2-low versus DYDC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYDC2→partner) and Y-score (partner→DYDC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.306	+2.820	<.001	.035	3	2
UCEC	C-Raf →	+0.227	+3.000	.006	.037	3	2
UCEC	JNK_pT183_Y185 →	-0.206	-2.986	.034	.037	3	1
UCEC	Caspase-8 →	-0.297	-3.000	.041	.036	2	2
SKCM	p21 →	-0.530	-2.982	.032	.036	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.577	-3.000	.026	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Notch1 by DYDC2 expression — UCEC

Explore this box plot interactively →