DVL3

Across TCGA patient cohorts, DVL3 protein abundance is significantly associated with the RNA expression of many other genes, with 6,451 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DVL3-associated genes across cancer lineages are LOXL1, COPZ2, and ADAMTS12. Each is linked with DVL3 in more than 7 cancer types. Because this analysis shows association rather than direction, both DVL3-to-partner and partner-to-DVL3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DVL3 versus LOXL1 in BRCA, with a Pearson correlation of 0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DVL3→partner) and Y-score (partner→DVL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LOXL1 →	+1.320	+0.262	<.001	<.001	3	8
BRCA	COPZ2 →	+1.427	+0.322	<.001	<.001	3	8
BRCA	ADAMTS12 →	+1.413	+0.321	<.001	<.001	3	8
BRCA	SPARC →	+1.620	+0.290	<.001	<.001	3	7
LSCC	NXN →	+0.856	+0.282	<.001	<.001	3	7
BRCA	FAP →	+1.592	+0.288	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,451 associations by consensus.

DVL3 vs LOXL1 — BRCA

Explore this scatter interactively →