DVL3

Across TCGA patient cohorts, DVL3 mutation is significantly associated with the RNA expression of many other genes, with 1,613 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DVL3-associated genes across cancer lineages are RNU6-1294P, POLE2, and LHX1-DT. Each is linked with DVL3 in more than 2 cancer types. Because this analysis shows association rather than direction, both DVL3-to-partner and partner-to-DVL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1294P grouped by DVL3-low versus DVL3-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DVL3→partner) and Y-score (partner→DVL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-1294P →	+0.328	+3.478	.002	.008	3	3
UCEC	POLE2 →	+0.436	+2.343	.004	.003	3	3
READ	LHX1-DT →	+0.316	+4.203	<.001	.003	3	2
READ	RNU6-142P →	+0.269	+4.672	<.001	.004	3	2
READ	LDHAL6DP →	+0.051	+5.096	<.001	.002	3	2
READ	SNORA74C-1 →	+0.282	+3.724	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,613 associations by consensus.

RNU6-1294P by DVL3 expression — HNSC

Explore this box plot interactively →