DVL3

Across TCGA patient cohorts, DVL3 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DVL3-associated genes across cancer lineages are ATM, PEA-15_pS116, and 4E-BP1. Each is linked with DVL3 in more than 2 cancer types. Because this analysis shows association rather than direction, both DVL3-to-partner and partner-to-DVL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by DVL3-low versus DVL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DVL3→partner) and Y-score (partner→DVL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.469	-1.807	.004	.025	3	3
UCEC	PEA-15_pS116 →	+0.311	+1.502	.015	.030	3	2
UCEC	4E-BP1 →	+0.230	+3.321	.020	.009	3	2
UCEC	14-3-3_beta →	-0.144	-2.780	<.001	.003	3	1
UCEC	eIF4E →	+0.209	+2.247	.007	.001	3	1
UCEC	ERK2 →	+0.210	+3.584	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

ATM by DVL3 expression — UCEC

Explore this box plot interactively →