DVL3

Across TCGA cell cohorts, DVL3 mutation is significantly associated with the RNA expression of many other genes, with 230 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DVL3-associated genes across cancer lineages are BBS7, DRAM2, and EXTL2. Each is linked with DVL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DVL3-to-partner and partner-to-DVL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BBS7 grouped by DVL3-low versus DVL3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DVL3→partner) and Y-score (partner→DVL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BBS7 →	+0.469	+3.523	.009	<.001	3	2
LARGE_INTESTINE	DRAM2 →	+0.451	+2.386	.006	.007	3	2
LARGE_INTESTINE	EXTL2 →	+0.600	+2.158	.009	.004	3	2
LARGE_INTESTINE	C1orf189 →	+0.077	+1.691	<.001	.009	3	2
LARGE_INTESTINE	PROP1 →	+0.013	+1.691	.002	.009	3	2
BLOOD_Leukemia	C2orf73 →	+0.041	+3.187	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 230 associations by consensus.

BBS7 by DVL3 expression — LARGE_INTESTINE

Explore this box plot interactively →