DVL2

Across TCGA pan-cancer cohorts, DVL2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated DVL2 data layer compared with 25 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher DVL2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated DVL2 expression acts as an unfavorable survival marker, although some lineages such as LUAD and CCRCC show a favorable association.

UCEC, LUAD, and CCRCC are the cancer types where DVL2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	II,III,IV	0.659	1.000	.021	12	view →
LUAD	OS	Median	II,III,IV	1.000	0.868	.006	9	view →
CCRCC	DFS	Tertile	IV	0.961	0.113	.024	6	view →
LSCC	DFS	Tertile	All	1.000	0.953	.017	5	view →
GBM	DFS	Tertile	All	0.458	0.314	.048	4	view →
PDAC	OS	Quartile	II,III,IV	0.381	0.629	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

DVL2–UCEC (OS)

Open the UCEC breakdown →