DVL2

Across TCGA patient cohorts, DVL2 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DVL2-associated genes across cancer lineages are eIF4E, ERK2, and Notch1. Each is linked with DVL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DVL2-to-partner and partner-to-DVL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by DVL2-low versus DVL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DVL2→partner) and Y-score (partner→DVL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.190	+3.472	.009	.002	3	2
UCEC	ERK2 →	+0.178	+1.736	.007	.007	3	2
UCEC	Notch1 →	+0.245	+2.459	<.001	<.001	3	2
UCEC	TFRC →	+0.562	+2.222	.002	.009	3	2
UCEC	Cyclin-B1 →	+0.586	+1.736	.002	.007	3	2
UCEC	14-3-3_beta →	-0.086	-2.432	.013	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

eIF4E by DVL2 expression — UCEC

Explore this box plot interactively →