DVL2

Across TCGA cell cohorts, DVL2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,158 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DVL2-associated GO terms across cancer lineages are Positive regulation of double-strand break repair, Positive regulation of DNA recombination, and Positive regulation of DNA repair. Each is linked with DVL2 in more than 18 cancer types. Because this analysis shows association rather than direction, both DVL2-to-partner and partner-to-DVL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of double-strand break repair grouped by DVL2-low versus DVL2-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DVL2→partner) and Y-score (partner→DVL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Positive regulation of double-strand break repair →	+0.083	+0.677	<.001	<.001	3	19
STOMACH	Positive regulation of DNA recombination →	+0.095	+0.818	.001	<.001	3	18
LUNG_NSCLC_LUSC	Positive regulation of DNA repair →	+0.062	+1.119	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Nuclear export →	+0.115	+1.212	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	RNA localization →	+0.118	+1.308	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Establishment of RNA localization →	+0.130	+1.259	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,158 associations by consensus.

Positive regulation of double-strand break repair by DVL2 expression — SOFT_TISSUE

Explore this box plot interactively →