DVL1

Across TCGA pan-cancer cohorts, DVL1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DVL1 data layer compared with 27 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher DVL1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated DVL1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

PDAC, LUAD, and GBM are the cancer types where DVL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	All	0.285	0.776	<.001	57	view →
LUAD	DFS	Median	II,III,IV	0.290	0.716	<.001	44	view →
GBM	OS	Median	All	0.637	0.887	.007	6	view →
HNSC	OS	Tertile	All	0.907	0.776	.033	6	view →
CCRCC	DFS	Tertile	All	0.876	0.643	.035	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DVL1–PDAC (OS)

Open the PDAC breakdown →