DVL1

Across TCGA patient cohorts, DVL1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DVL1-associated genes across cancer lineages are Caspase-7-cleavedD198, 4E-BP1, and Fibronectin. Each is linked with DVL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DVL1-to-partner and partner-to-DVL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by DVL1-low versus DVL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DVL1→partner) and Y-score (partner→DVL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.987	+2.827	.001	.035	3	2
UCEC	4E-BP1 →	+0.554	+2.837	<.001	.035	3	2
UCEC	Fibronectin →	-0.508	-3.321	.003	.010	3	1
UCEC	PI3K-p85 →	+0.240	+3.321	.028	.010	3	1
UCEC	Annexin-1 →	+0.964	+3.321	<.001	.010	3	1
UCEC	14-3-3_beta →	-0.151	-3.308	.004	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Caspase-7-cleavedD198 by DVL1 expression — UCEC

Explore this box plot interactively →