DVL1

Across TCGA cell cohorts, DVL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,434 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DVL1-associated GO terms across cancer lineages are Negative regulation of small GTPase mediated signal transduction, Positive regulation of proteasomal ubiquitin-dependent protein catabolic process, and Protein K29-linked ubiquitination. Each is linked with DVL1 in more than 13 cancer types. Because this analysis shows association rather than direction, both DVL1-to-partner and partner-to-DVL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of small GTPase mediated signal transduction grouped by DVL1-low versus DVL1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DVL1→partner) and Y-score (partner→DVL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of small GTPase mediated signal transduction →	+0.067	+0.663	<.001	.003	2	14
BONE	Positive regulation of proteasomal ubiquitin-dependent protein catabolic process →	+0.053	+0.821	.003	.002	3	12
BONE	Protein K29-linked ubiquitination →	+0.108	+1.035	.002	.001	3	12
BONE	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.158	+1.272	<.001	<.001	3	12
OESOPHAGUS	Regulation of autophagy of mitochondrion →	+0.109	+0.853	<.001	.004	3	12
BONE	Actomyosin contractile ring assembly actin filament organization →	+0.195	+0.897	.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,434 associations by consensus.

Negative regulation of small GTPase mediated signal transduction by DVL1 expression — UPPER_AERODIGESTIVE_TRACT

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