DUXB

Across TCGA patient cohorts, DUXB RNA expression is significantly associated with the protein abundance of many other proteins, with 11,736 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible DUXB-associated proteins across cancer lineages are HDGFL3, SERBP1_S197, and THSD4. Each is linked with DUXB in more than 5 cancer types. Because this analysis shows association rather than direction, both DUXB-to-partner and partner-to-DUXB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DUXB versus HDGFL3 in GBM, with a Pearson correlation of 0.37.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DUXB→partner) and Y-score (partner→DUXB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HDGFL3 →	+0.517	+0.604	<.001	<.001	3	6
HNSC	SERBP1_S197 →	-0.484	-0.447	<.001	.003	3	5
BRCA	THSD4 →	+0.717	+0.314	<.001	<.001	3	4
BRCA	UBA1_S835 →	-0.594	-0.281	<.001	.001	3	4
GBM	WDR37 →	+0.259	+0.525	.006	.004	3	4
UCEC	PHF1 →	+0.319	+0.667	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,736 associations by consensus.

DUXB vs HDGFL3 — GBM

Explore this scatter interactively →