DUXAP2

Across TCGA pan-cancer cohorts, DUXAP2 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of DUXAP2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where DUXAP2 RNA is repressed in tumor relative to normal tissue. In most cancer types DUXAP2 is over-expressed in tumor, although a few such as HNSC and COAD show the opposite, repressed pattern.

HNSC, COAD, and BLCA are the cancer types where DUXAP2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DUXAP2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	−0.247	<.001	10	view →
COAD	All	II,III,IV	−0.065	.001	7	view →
BLCA	All	All	+0.380	.032	3	view →
LUSC	All	All	+0.061	.011	2	view →
PRAD	All	All	+0.056	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

DUXAP2–HNSC

Open the HNSC breakdown →