DUX4L8

Across TCGA pan-cancer cohorts, DUX4L8 RNA is linked to patient survival in 6 of 34 cancer types, making it the most broadly survival-associated DUX4L8 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DUX4L8 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DUX4L8 expression acts as an unfavorable survival marker.

HNSC, STAD, and KIRC are the cancer types where DUX4L8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.100	0.710	<.001	126	view →
STAD	DFS	Tertile	All	0.186	0.563	<.001	72	view →
KIRC	DFS	Tertile	All	0.252	0.796	.009	36	view →
BRCA	DFS	Tertile	All	0.321	0.903	.002	36	view →
CESC	OS	Tertile	All	0.459	0.800	.024	18	view →
LUAD	OS	Tertile	All	0.301	0.698	.045	9	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

DUX4L8–HNSC (DFS)

Open the HNSC breakdown →