DUX4L50

Across TCGA pan-cancer cohorts, DUX4L50 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated DUX4L50 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher DUX4L50 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DUX4L50 expression acts as an unfavorable survival marker, although some lineages such as UCS and LGG show a favorable association.

KIRC, UCS, and UCEC are the cancer types where DUX4L50 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.521	0.756	<.001	128	view →
UCS	DFS	Tertile	II,III,IV	0.651	0.260	.009	66	view →
UCEC	OS	Tertile	All	0.612	0.847	.001	50	view →
ACC	DFS	Quartile	All	0.131	0.846	<.001	50	view →
DLBC	DFS	Tertile	III,IV	0.130	1.000	.004	45	view →
LGG	OS	Median	All	0.865	0.747	<.001	34	view →
BRCA	OS	Tertile	II,III,IV	0.972	0.939	.007	26	view →
PAAD	DFS	Tertile	All	0.499	0.244	.006	25	view →
ESCA	DFS	Quartile	All	0.685	0.174	.007	21	view →
SKCM	OS	Tertile	All	0.792	0.690	.003	17	view →
COAD	OS	Median	IV	0.296	0.640	.017	14	view →
PCPG	OS	Median	All	0.928	1.000	.009	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

DUX4L50–KIRC (OS)

Open the KIRC breakdown →