DUT

Across TCGA pan-cancer cohorts, DUT mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DUT data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DUT mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated DUT expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

HNSC, LUAD, and CCRCC are the cancer types where DUT mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.296	1.000	.003	25	view →
LUAD	OS	Quartile	All	0.601	1.000	.004	16	view →
CCRCC	DFS	Tertile	III,IV	0.314	0.701	.003	9	view →
PDAC	DFS	Tertile	All	0.847	0.558	.031	5	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

DUT–HNSC (OS)

Open the HNSC breakdown →