DUT

Across TCGA patient cohorts, DUT mutation is significantly associated with the RNA expression of many other genes, with 672 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DUT-associated genes across cancer lineages are RNU6-225P, TCP11X3P, and TRAV37. Each is linked with DUT in more than 1 cancer types. Because this analysis shows association rather than direction, both DUT-to-partner and partner-to-DUT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-225P grouped by DUT-low versus DUT-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DUT→partner) and Y-score (partner→DUT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-225P →	+0.262	+4.385	<.001	.008	3	2
UCEC	TCP11X3P →	+0.268	+2.117	.001	.008	3	2
UCEC	TRAV37 →	+0.112	+3.250	<.001	.001	3	2
BRCA	MIR4462 →	+0.544	+5.045	.001	.009	3	2
READ	PGBD4P2 →	+0.162	+6.257	<.001	.001	3	1
BLCA	RNU7-9P →	+0.512	+7.640	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 672 associations by consensus.

RNU6-225P by DUT expression — SKCM

Explore this box plot interactively →