DUT

Across TCGA cell cohorts, DUT RNA expression is significantly associated with the go_rna of many other GO terms, with 3,910 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DUT-associated GO terms across cancer lineages are Regulation of cell cycle checkpoint, Spindle elongation, and Mitotic DNA replication. Each is linked with DUT in more than 16 cancer types. Because this analysis shows association rather than direction, both DUT-to-partner and partner-to-DUT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cell cycle checkpoint grouped by DUT-low versus DUT-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DUT→partner) and Y-score (partner→DUT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of cell cycle checkpoint →	+0.098	+1.112	.001	<.001	3	17
BLOOD_Myeloma	Spindle elongation →	+0.300	+1.043	<.001	<.001	3	17
BLOOD_Myeloma	Mitotic DNA replication →	+0.216	+1.132	<.001	<.001	3	16
PANCREAS	Regulation of chromosome separation →	+0.120	+0.601	<.001	<.001	3	16
LUNG_NSCLC_LUSC	Regulation of DNA damage checkpoint →	+0.101	+1.031	<.001	.003	3	16
BONE	Replication fork processing →	+0.112	+0.860	.009	.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,910 associations by consensus.

Regulation of cell cycle checkpoint by DUT expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →