DUSP6

Across TCGA pan-cancer cohorts, DUSP6 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated DUSP6 data layer compared with 26 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher DUSP6 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DUSP6 expression acts as an unfavorable survival marker.

BLCA, HNSC, and THCA are the cancer types where DUSP6 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	III,IV	0.082	0.582	<.001	39	view →
HNSC	OS	Median	All	0.162	0.685	.018	24	view →
THCA	OS	Median	All	0.342	0.955	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

DUSP6–BLCA (OS)

Open the BLCA breakdown →